lhrh receptor การใช้

The specific targeting of the doxorubicin to LHRH receptor bearing cells is also proposed to reduce the cardiotoxicity observed in the administration of unconjugated doxorubicin.
For example, one of the most promising application is through peptides that target LHRH . These particular peptides act as an agonist, meaning that they bind to a cell in a way that regulates LHRH receptors.
The proposed method of action is that upon administration zoptarelin doxorubicin binds to the LHRH receptor and is subsequently internalized, concentrating the toxic doxorubicin within cancer cells and the small subset of normal tissues, as opposed to the completely systemic distribution observed with untargeted chemotherapeutics.